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The purpose of this study was to assess if microvolt T-wave alternans (MTWA) is an independent predictor of mortality in patients with ischemic cardiomyopathy.

Microvolt T-wave alternans has been proposed as an effective tool for identifying high-risk patients with ischemic cardiomyopathy who are likely to benefit from implantable cardioverter-defibrillator (ICD) therapy. However, earlier studies have been limited in their ability to control for baseline differences between MTWA-negative and -non-negative (positive and indeterminate) patients.

Theodore Chow, MD, FACC, Dean J. Kereiakes, MD, FACC, Cheryl Bartone, RN, Terri Booth, RN, Edward J. Schloss, MD, FACC, Theodore Waller, MD, FACC, Eugene S. Chung, MD, Santosh Menon, MD, Brahmajee K. Nallamothu, MD, MPH and Paul S. Chan, MD, MSc

Journal of the American College of Cardiology, (47) 9: 1820 – 1827, May 2, 2006.